Most of his work concerns the interface between Mexican and U.S. culture. His interdisciplinary projects and books explore borders, physical, cultural and otherwise, between his two countries and between the mainstream U.S. and Latino cultures in general: the U.S.-Mexican border itself, immigration, cross-cultural identity, and the confrontation and misunderstandings between cultures and races. His artwork also explores the politics of language, the side effects of globalization and new technologies. Gómez-Peña's performance art often involves elaborate costuming and other collaborators, including Roberto Sifuentes and Coco Fusco. He has worked in multiple media, including radio, video, and installation art, and his eight books include poetry, essays, and chronicles in both English and Spanish (and Spanglish).